Acknowledgements . . . . . . . . . .

Preface . . . . . . . . . .

Foreword by Dr. John L. Gedye . . . . . . . . . .

Introduction by Dr. John C. Lowe . . . . . . . . . .
Section I Fibromyalgia:
The New Imperative
Chapter
1.1 Fall of the Rheumatology Paradigm and the New Imperative . . . .

Chapter 1.2 Fibromyalgia
is Not a "Somatoform Disorder
. . . . . . . . . .
Section II Background:
Basic and Clinical Sciences
Chapter 2.1 Thyroid Hormone Physiology
. . . . . . . . . .

Chapter 2.2 Cellular Actions of Thyroid Hormones
. . . . . . . . . .
Chapter 2.3 Genomic Actions and Molecular Biology
of Thyroid Hormones . . .
Chapter 2.4 Thyroid Hormone Deficiency
. . . . . . . . . .
Chapter 2.5 Euthyroid Hypometabolism
. . . . . . . . . .
Chapter 2.6 Thyroid Hormone Resistance
. . . . . . . . . .
| Section III |
Interpretation
of Fibromyalgia |
|
Symptoms and Objective Findings as
Manifestations of Inadequate Thyroid
Hormone Regulation |
Section III-A System Mechanisms
Chapter 3.1 Adrenergic System . . . . . . . . . .
Chapter 3.2 Blood Pressure and Circulation . . . . . . . . . .
Chapter 3.3 Connective Tissue . . . . . . . . . .
Chapter 3.4 Fitness and Exercise Intolerance . . . . . . . . . ..
Chapter 3.5 Hypothalamic-Pituitary-Adrenal Axis . . . . . . . . . .
Chapter 3.6 Sex Hormones: Hypothalamic-Pituitary-Gonadal Axis . . . . . . .
Section III-B Mechanisms Underlying
Particular
Signs, Symptoms and Objective Findings
Chapter 3.9 Cold and Heat Intolerance . . . . . . . . . .
Chapter 3.10 Depression, Anxiety, and
Cognitive Dysfunction . . . . . . . . . .
Chapter 3.11 Fatigue and Flexed Posture . . . . . . . . . .
Chapter 3.12 Growth Hormone and Somatomedin C . . . . . . . . . .
Chapter 3.13 Immune Dysregulation . . . . . . . . . .
Chapter 3.14 Irritable Bowel Syndrome . . . . . . . . . .
Chapter 3.15 Pain . . . . . . . . . .
Chapter 3.16 Paresthesia . . . . . . . . . .
Chapter 3.17 Sicca-Like Membranes and Dry Skin . . . . . . . . . .
Chapter 3.18 Sleep Disturbance . . . . . . . . . .
Chapter 3.19 Substance P . . . . . . . . . .
Chapter 3.20 Swelling and Stiffness . . . . . . . . . .
Chapter 3.21 Urinary Frequency and
Urgency . . . . . . . . . .
Section IV Diagnosis
and Assessment
Chapter 4.1 Diagnosis of Fibromyalgia and Evaluation
of the
Patient’s Changing Status . . . . . . . . . .
Chapter 4.2 Laboratory Evaluation of Thyroid Status . . . . . . . . . .
Chapter 4.3 Symptoms, Signs, and Peripheral Indices . . . . . . . . . .
Chapter 4.4 Adverse Effects of Excessive and Inadequate
Thyroid Hormone . .
Section IV Treatment:
Metabolic Rehabilitation
Chapter 5.1 Review of Studies: Fibromyalgia Treatments . . . . . . . . . .
Chapter 5.2 Treatment Protocol . . . . . . . . . .
Chapter 5.3 T4 (Thyroxine) and Combined T4/T3
Preparations:
Considerations for the Treatment of Hypothyroid Fibromyalgia . . . . . . . . . .
Chapter 5.4 T3 (Triiodothyronine): Considerations for
the
Treatment of Fibromyalgia . . . . . . . . . .
Chapter 5.5 Complementary Methods: Increasing Metabolic
Capacity and Decreasing Metabolic Demand . . . . . . . . . .
Appendices
Appendix A
Fibromyalgia Assessment Forms and Blank Line Graphs .
. . . . . . . . .
Appendix B
Published Papers on Fibromyalgia by Dr. John C. Lowe and Colleagues
. . . .
Appendix C
Debate with Michael Weintraub, M.D. . . . .
. . . . . .
Appendix D
Conversions: T4, T3, and Desiccated
Thyroid . . . . . . . . . .
Glossary
Index
McDowell
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